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Better Understanding of How Cranberry Fights UTIs
 Cranberry juice has been used as a traditional folk remedy for urinary tract infections (UTIs) for decades, perhaps centuries. Research has supported this folk remedy and indicated that cranberry can be highly effective in the treatment and prevention of UTIs. Now scientist are closer to understanding how cranberry works.1 Researchers from Worchester Polytechnic Institute (WTI) in Massachesettes presented a paper at the annual meeting of the American Chemical Society in San Francisco on September 10 that reveals some insight into how cranberry juice prevents UTIs. It has long been suspected that compounds found in cranberries somehow prevent bacteria from attaching to host cells, thereby preventing the bacteria from becoming established in the body. It was believed that a group of chemical compounds called proanthocyanidins where the active constituent in cranberries. The researchers studied these proanthocyanidins by culturing E. coli bacteria in varying concentrations of cranberry juice or proanthocyanidins. It turns out that the proanthocyanidins do prevent the bacteria from adhering to host cells, but that's not the full story. The researchers found that the cranberry compounds caused the bacteria to change their shape from rods to spherical which caused the bacteria to alter their cell membrane, changing their behavior. E. Coli are gram-negative bacteria. The changes to their membrane, caused them to begin acting like gram-positive bacteria. None of these behaviors have ever been witnessed in E. coli before. And there was one other significant finding. Bacteria, as individuals cannot make a person sick. There needs to be enough bacteria present to produce enough of the toxins that will make someone sick. Bacteria communicate chemically with one another in order to coordinate their attack. The researchers found that the cranberry juice prevented the chemical communication between the bacteria, thus keeping them from attacking the host with their toxins. All these findings make this very exciting research in the world of science. And, more importantly, they demonstrate that cranberry extract and proanthocyanidins may be exceptionally potent antibacterial agents. The lead researcher Dr. Terri Camesano stated "these results are surprising and intriguing, particularly given the increasing concern about the growing resistance of certain disease-causing bacteria to antibiotics." The greater the concentration of proanthocyanidins, the greater the effects on the bacteria, suggesting that extracts and highly concentrated juices have the greatest health benefits. Did you know that most of the cranberry juice products that are readily available in grocery stores can actually make UTI's worse due to the high levels of added sugar? Each capsules of our CranberryHealth supplement contains 400mg of a potent 2 to 1 extract (with no sugar added of course) plus 40mg of Vitamin C. 1. Camesano, T., Y. Liu, et al. (2006). Compounds in Cranberry Juice Show Promise as Alternatives to Antibiotics for Treating a Host of Human Illnesses. Annual Meeting of American Chemical Society, San Francisco.
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