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MSM
What Is MSM?
MSM is used as a dietary supplement to provide our bodies with needed sulfur. Supplementing with MSM may help to reduce the pain of arthritis, muscle soreness and cramping, and to alleviate allergies. MSM may help relieve joint pain and swelling - without the stomach damage, rebound pain, and joint damage associated with non-steroidal anti-inflammatory drugs (NSAID's), such as ibuprofen.
Why Is Our MSM Better?
Not all MSM is the same - only Lignisul™ brand MSM from Carolwood Corporation is guaranteed at least 99.7% pure as determined by gas chromatographic assay. EVERY batch produced by Carolwood has been tested! The first food-grade MSM made for human consumption; Lignisul™ remains the finest available. You're taking MSM to improve your health - don't take inferior MSM.
Methylsulfonylmethane, or MSM, is a safe and natural assimilate derived from the Southern Louisiana Pine. MSM is organic sulfur--the kind your body can absorb and use. Sulfur is the fourth most plentiful mineral in the body. And, it is found in every cell of every animal and plant. Sulfur is found in food; it is most abundant in eggs and red peppers, but can also be found in significant quantities in grains, legumes, animal proteins, onions, garlic, asparagus, cabbage, brussels sprouts, and broccoli. However, most of the volatile MSM is lost in washing, cooking, or steaming. Modern food processing, packaging and preparation has robbed our food of the sulfur we need.
At the Oregon Health and Sciences University, Dr. Stanley Jacob discovered that heating dimethyl sulfoxide (DMSO), caused it to crystallize, isolating 99.9% of the beneficial compound MSM. MSM is a pure, natural, stable, white, odorless crystalline powder without the unpleasant taste or odor of DMSO. It does not produce intestinal gas or body odor that may occur with other forms of sulfur. MSM is not a drug or medicine, and is unrelated to sulfa drugs, to which some people have an allergy.
Interstitial Cystitis (IC) and MSM:
Dimethyl Sulfone (DMSO) has long been used for the treatment of IC. Lately, Dr. Stanley Jacob at the Oregon Science and Health University has done pioneering work with MSM, particularly in the treatment of Interstitial Cystitis. He has found that patients better tolerate MSM. This is a huge consideration in Interstitial Cystitis since patients often struggle with severe reactions to treatments and foods that they consume. He has also found comparable efficacy for reducing inflammation and reducing pain and other symptoms. His treatments are a combination of IV, oral and topical methodologies. For those of you who suffer fom Interstitial Cystitis, we encourage you to discuss MSM with your medical practitioner and consider it as an adjunct to your IC treatment. If you decide to use MSM on your own for IC, please make sure you discuss and/or disclose this to your doctor.
How Should MSM Be Used?
Results vary. According to Dr. Earl L. Mindell, R.Ph., Ph.D., "Due to its positive wide-spectrum effect, particularly in maintaining healthy cell formation, dietary nutritional supplementation of MSM is recommended at a daily rate of 2,000 to 6,000mg. The optimum effective dosage would depend on body size, age, the MSM blood level prior to administration, and the nature and severity of the condition you are treating. This means you can experiment with different doses to find out what works best for you." Sometimes, it takes up to 3 weeks for effects to be noticed.
References
MSM Further Reading
For further reading, we recommend:
Mindell, E. L., The MSM Miracle: Enhance your health with organic sulfur. Keats Publishing, New Canaan, CT, 1997.
Bartfeld, I. J., Goldstein, A., "Cell-mediated Immunity: Its Modulation by Dimethylsulfoxide," Ann. N. Y. Acad. Sci., 1975.
Childs, S. J., "Dimethylsulfone (DSM02) in the Treatment of INterstitial Cystitis." Urol. Clin. North Am., 1994.
Cooper, A., "Biochemistry of Sulfur-containing Amino Acids," Ann. Rev. Biochem., 1983.
D'Ambrosia, E, Casa, B., Bompani R., Scali, M., "Glucosamine Sulphate: A Controlled Clinical Investigation in Arthosis," Pharmatherapeutica, 1981.
Herschler, R. J., "Methysulfonylmethane and Methods of Use," United States Patent 4,296,130: 1981.
Herschler, R. J., "Methysulfonylmethane and Compositions Comprising It," United States Patent 4,616,039: 1986.
Herschler, R. J., "Dietary and Pharmaceutical uses of Methysulfonylmethane Compositions Comprising It," United States Patent 4,512,421:
Jacob, S. W., "The Current Status of MSM in Medicine," Am. Acad. Meri. Prev., 1983.
Jacob, S. W., Herschler R. J., "Introdry Remarks: Dimethylsulfoxide After Twenty Years," Ann. N. Y. Acad. Sci., 1983.
Kharasch, N., Thyagarajan, B. S., "Structural Basis for Biological Activities of Dimethylsulfoxide," Ann. N. Y. Acad. Sci., 1983.
Klein, H. A., Samant, S., Herz, B. L., Pearlman, H. S., "Dimethylsulfoxide in Adult Respiratory Stress Syndrome," Ann. N. Y. Acad. Sci., 1983.
Koesis, J. J., Harkaway, S, Snyder, R., "Biological Effects of the Metabolites of Dimethylsulfoxide," Ann. N. Y. Acad. Sci., 1975.
Metcalf, J. W., "MSM--A Dietary Derivative of DSMO," J. Eq. Vet. Sci., 1983.
Metcalf, J. W., "MSM Status Report," Eq. Vet. Data, 1986.
Miura K et al., "Cystine Uptake and Glutathione Level in Endothelial Cells Exposed to Oxidative Stress," Am. J. Physiol., 1992.
Morton, J. i., Siegel, B. V., "Effects of Oral Dimethylsulfoxide and Dimethylsulfone on Murine Autoimmune Lymphoproliferative Disease," Proc. Soc. Exper. Bio. Med., 1986.
Nagasawa, H., "The In Vitro and In Vivo EffectS Dimethylsulfoxide on the Pituitary Secretion of Growth Hormone and Prolactin in Mice," Ann. N. Y. Acad. Sci., 1983.
Pearson, T. W., Dawson, H. J., Lackey, H. B., "Natural Occurring Levels of Dimethylsulfoxide in Selected Fruits, Vegetables, Grains and Beverages," J. Agric. Food Chem., 1981.
Repine, J. E., Fox, R. B., Berger, E. M., "Effect of Dimethylsulfoxide on the Bactericidal Function of Polymorphonuclear Leukocytes," Ann. N.Y. Acad. Sci., 1983.
Richmond, V. L., "lncorporation of Methylsulfonylmethane Into Guinea Pig Serum Proteins," Life Sciences, 1986.
Richmond, V. L., "Incorporation of Methylsulfonylmethane into Guinea Pig IgG, Transferrin and Albumin Fractions and Tissues," Seattle, Wash: Pacific Northwest Research Foundation.
Sellnow, I., "MSM--An Aid From Nature," Canadian Horseman, 1989.
Tapadinhas, M. J., Rivera, I. C., Bignamini, A. A., "Oral Glucosamine Sulfate in the Management of Arthrosis," Report on a Multi-center Open Investigation in Portugal, 1982. IL
Teigland, M. B., Saurino, V. R., "Clinical Evaluation of Dimethylsulfoxide in Equine Applications," Ann. N. Y. Acad. Sci., 1975.
Voaden. M. J; Hussain. A.A.; Chan, I. P. R. "Studies on Retinitis Pigmentosa in Man. I. Taurine and Blood Platelets." Brit. J. Opthal., 1982.
Williamson, J., Boettcher, B., Meister, A., "lntracellular Cysteine Delivery System that Protects Against Toxicity by Promoting Glutathione Synthesis," Proc. Nat. Acad. Sci., 1982.
Wright, J., Littleton, K., "Defects in Sulfur Metabolism," Intl. Clin. Nutr. Rev., 1989.
Wright, J., Kirk, F. R., "Defects in Sulfur Metabolism II: Apparent Failure of Sulphate Conjugation," Intl. Clin. Nutr. Rev., 1989.
This website and these statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease. Please consult a properly trained medical practitioner for medical advice.