Over 10,000 customers have rated this store since 1999
PomeHealth™ Pomegranate with Trans-Resveratrol (60 capsules)
PM1
(10-30 Day Supply)
IN STOCK - YES
What is Pomegranate & Resveratrol Blend? PomeHealth™ Pomegranate & Resveratrol Antioxidant Blend is a collection of significant antioxidants to protect against oxidative damage on a cellular level and promote proper immune system function. The formula includes pomegranate, trans-resveratrol (from Japanese knotweed) and grape skin extract. People with compromised immune systems, circulation concerns, high LDL cholesterol and those with poor dietary intake could all benefit from the powerful effects of antioxidants in this wonderful formula. Pomegranate, individually, has recently been shown to provide tremendous support to prostate health.
Why Is Our Pomegranate & Resveratrol Blend Better? Our unique PomeHealth™ is a synergistic blend of three of the most powerful natural antioxidants available. Numerous studies have linked these three ingredients to potential heart and cardiovascular system benefits. This formulation delivers all three ingredients in one economical product, only available at Whole Health.
Who Should Consider Pomegranate & Resveratrol Blend? Everyone, but especially people with high LDL cholesterol levels, cardiovascular concerns, those seeking support for their prostate health, and those with a low dietary intake of antioxidants.
Pomegranate extract, grape skin extract and resveratrol provide a powerful collection of significant antioxidants which protect against oxidative damage on a cellular level and promote good cardiovascular health.
To be sure you never run out of your favorite products, we now offer our exclusive
Convenience Plan. This plan guarantees delivery of our
high quality products directly
to your door exactly when you need them. Additionally, you receive our lowest price on
each order. It is simple, convenient and free! And, you can change, add to, suspend or
cancel shipments at any time!
What is Resveratrol?
Resveratrol is a phenolic compound that has been found to have strong antioxidant activity. Plants create resveratrol to protect themselves against the effects of poor growing conditions and severe weather. Resveratrol has been shown to reduce the oxidation of LDL cholesterol, total cholesterol and lower the risk of cardiovascular disease. There have been numerous studies that show the benefits of moderate red wine consumption on health. Red wine is fermented with the antioxidant-potent grape skins present; some studies suggest that the intake of red wine (and therefore resveratrol) may yield cholesterol-lowering effects. This is one way that red wine consumption protects the heart.3 In addition to red wine and grape skin, Japanese Knotweed is an excellent source of resveratrol.
What is Pomegranate?
A pomegranate is the delicious, seedy fruit from the pomegranate tree, and has long been used in Traditional Eastern Medicines for treating diseases and infections.
Recently there has been much interest in medical research on the health benefits of this fruit. According to research pioneer Professor Michael Aviram of the Lipid Research Laboratory at the Technion-Israel of Technology, "Pomegranates are proving to be the most powerful antioxidant available, better than red wine, tomatoes, vitamin E and a variety of other headline makers."1
In addition to the seeds, skin and flesh, pomegranates are composed of alkaloids and polyphenols, phytochemicals that are potent antioxidants. The active constituent in pomegranate extract appears to be a phenolic compound known as ellagic acid. Ellagic acid occurs naturally in certain fruits and boasts antioxidant and anti-viral benefits. Like the polyphenolic component in green tea, as well as the polyphenolic component in red wine (resveratrol), ellagic acid imparts important antioxidant benefits to the user, including immune system support and a reduction in oxidation of LDL cholesterol. In addition, pomegranates have been shown to have three times the antioxidant effect of red wine or green tea.2
Our PomeHealth™ formula contains 40% standardized extract of ellagic acid.
What is Grape Skin Extract?
Grape skin extract is derived from the skins of red grapes, the same kind that are used to make wine. Grape skins are rich in compounds that protect the delicate flesh and seeds. The two most important of these compounds are resveratrol and a class of tannins called oligomeric procyanidins or OPCs. These OPC are also widely available in the seeds, but it is in fact the skins that give red wines their color, bitterness and many of their more complex flavors.
A study published in the November 28, 2006 issue of the journal Nature found that OPC did more to protect the heart than any other compounds in red wine.70 Putting that discovery to a "real-world" test, the researchers used French census data to determine that the men living in Sardinia and the Gers region of southwestern France had the longest life expectancies. Those regions also produce the wines with the highest OPC content, up to 4 times higher than other regions. Typically in wine making, grape skins are removed after a week to keep the bitter tannin levels low. However, in these regions the skins are often left to ferment in the wine for 4 weeks or more. This allows for more of the OPC to accumulate in the wines of Sardina and Gers.The most valuable flavonoids in grape skin extract are oligomeric procyanidins (also known as proanthocyanidins), commonly called OPCs. In addition to their antioxidant properties, OPCs are thought to improve blood circulation and help strengthen blood vessels.
What are antioxidants?
Antioxidants are compounds made from vitamins, minerals and enzymes that help protect our body from the oxidative damages of free radicals. Free radicals are highly reactive molecules that can bind to and destroy body components. Free radicals are unstable atoms or molecules with at least one unpaired electron that search the body for another electron to pair up with. If they find an electron, they take it and become stable. However, the process makes the atoms or molecules that they took the electron from unstable, thereby creating a new free radical. This free radical or 'oxidative' damage is what makes us age and is responsible for the initiation of many diseases, including heart disease and cancer. The serious damage from free radicals seems to come in the act of searching for, entering into and taking electrons from cells. This 'oxidization' activity damages cell structures, particularly the cellular plasma membranes. Plasma cell membranes are natural gate keepers for cells, deciding what comes and goes within the cell. Damaging the plasma cell membrane and/or having the presence of free radicals in the cell, can damage the cell's ability to generate energy (in the mitochondria organelles), damage the cell's nucleus or damage the cell's DNA. Through this process the use and movement of nutrients, oxygen, water, waste products and toxins can also be hindered.
We are exposed to free radicals everyday - from pesticides in the foods we eat, toxins in the water we drink, to the polluted air we breathe. Antioxidants can help stop or impede the activities and impacts of free radicals and play a role in reinforcing your overall health and resilience.
Suggested Use: As a dietary supplement, take two capsules 1-3 times daily with meals, or as directed by a health care practitioner.
Vcaps vegetarian capsule used and a vegetarian formula.
References
Aviram M, Dornfeld L, Rosenblat M, et al. Pomegranate juice consumption reduces oxidative stress, atherogenic modifications to LDL, and platelet aggregation: studies in humans and in atherosclerotic apolipoprotein E-deficient mice. Am J Clin Nutr. 2000 May;71(5):1062-76.
Gil MI, Tomas-Barberan FA, Hess-Pierce B, Holcroft DM, Kader AAAntioxidant activity of pomegranate juice and its relationship with phenolic composition and processing. J Agric Food Chem. 2000 Oct;48(10):4581-9.
Wang Z, Huang Y, Zou J, et al. Effects of red wine and wine polyphenol resveratrol on platelet aggregation in vivi and in vitro. J Mol Med 2002; 9(1):77-79.
Hadley CW, Miller EC, Schwartz SJ, Clinton SK. Tomatoes, lycopene, and prostate cancer: progress and promise. Exp Biol Med ( Maywood). Nov 2002;227(10):869-880.
Pastori M, Pfander H, Boscoboinik D, Azzi A. Lycopene in association with alpha-tocopherol inhibits at physiological concentrations proliferation of prostate carcinoma cells. Biochem Biophys Res Commun. 1998;250(3):582-585.
Gann PH, Khachik F. Tomatoes or lycopene versus prostate cancer: is evolution anti-reductionist? J Natl Cancer Inst. Nov 5 2003;95(21):1563-1565.
Etminan M, Takkouche B, Caamano-Isorna F. The role of tomato products and lycopene in the prevention of prostate cancer: a meta-analysis of observational studies. Cancer Epidemiol Biomarkers Prev. Mar 2004;13(3):340-345.
Giovannucci E, Ascherio A, Rimm EB, Stampfer MJ, Colditz GA, Willett WC. Intake of carotenoids and retinol in relation to risk of prostate cancer. J Natl Canc Inst. 1995;87:1767-1776.
Chen L, Stacewicz-Sapuntzakis M, Duncan C, et al. Oxidative DNA damage in prostate cancer patients consuming tomato sauce-based entrees as a whole-food intervention. J Natl Cancer Inst. 2001;93(24):1872-1879.
Chan JM, Stampfer MJ, Giovannucci E, et al. Plasma insulin-like growth factor-I and prostate cancer risk: A prospective study. Science. 1998;279:563-566.
Millen AE, Tucker MA, et. Al. Diet and Melanoma in a Case Control Study, Cancer Epidemiol Biomarkers Prev. 2004 Jun;13(6):1042-51.
Nkondjock A, Ghadirian P.. Dietary carotenoids and risk of colon cancer: case-control study. Int J Cancer 2004 May 20;110(1):110-6.
Murtaugh MA, Ma KN, et al. Antioxidants, carotenoids, and risk of rectal cancer. Am J Epidemiol. 2004 Jan 1;159(1):32-41.
Kohlmeier L, Kark JD, GomezGracia E, et al. Lycopene and myocardial infarction risk in the EURAMIC Study. Am J Epidemiol. 1997;146:618-626 12. Truswell AS. ABC of nutrition. Nutrition for pregnancy. Br Med J 1985;291:263-6.
Klipstein-Grobusch K, Launer LJ, Geleijnse JM, Boeing H, Hofman A, Witteman JC. Serum carotenoids and atherosclerosis. The Rotterdam Study. Atherosclerosis. 2000;148(1):49-56.
Rissanen TH, Voutilainen S, Nyyssonen K, et al. Low serum lycopene concentration is associated with an excess incidence of acute coronary events and stroke: the Kuopio Ischaemic Heart Disease Risk Factor Study. Br J Nutr. 2001;85(6):749-754.
Rissanen TH, Voutilainen S, Nyyssonen K, Salonen R, Kaplan GA, Salonen JT. Serum lycopene concentrations and carotid atherosclerosis: the Kuopio Ischaemic Heart Disease Risk Factor Study. Am J Clin Nutr. Jan 2003;77(1):133-138.
Kristenson M, Zieden B, Kucinskiene Z, et al. Antioxidant state and mortality from coronary heart disease in Lithuanian and Swedish men: concomitant cross sectional study of men aged 50. BMJ. 1997;314(7081):629-633.
Sesso HD, Buring JE, Norkus EP, Gaziano JM. Plasma lycopene, other carotenoids, and retinol and the risk of cardiovascular disease in women. Am J Clin Nutr. Jan 2004;79(1):47-53.
Sesso HD, Liu S, Gaziano JM, Buring JE. Dietary lycopene, tomato-based food products and cardiovascular disease in women. J Nutr. Jul 2003;133(7):2336-2341.
Wood N, Johnson RB. The relationship between tomato intake and congestive heart failure risk in periodontitis subjects. J Clin Periodontol. 2004 Jul;31(7):574-80.
Hak, A. Stroke: Journal of the American Heart Association, June 4, 2004; vol 35. News release, American Heart Association.
Hak AE, Ma J, , et al. Prospective Study of Plasma Carotenoids and Tocopherols in Relation to Risk of Ischemic Stroke , Stroke. 2004 Jun 3.
Xu Y, Leo MA, Lieber CS. Lycopene attenuates alcoholic apoptosis in HepG2 cells expressing CYP2E1. Biochem Biophys Res Commun. 2003 Aug 29;308(3):614-8.
Simonelli F, Zarrilli F, Mazzeo S. Serum oxidative and antioxidant parameters in a group of Italian patients with age-related maculopathy. . Clin Chim Acta. 2002 Jun;320(1-2):111-5.
Chew BP, Park JS. Carotenoid action on the immune response . J Nutr. 2004 Jan;134(1):257S-261S.
Mertens-Talcott SU, Percival SS. Ellagic acid and quercetin interact synergistically with resveratrol in the induction of apoptosis and cause transient cell cycle arrest in human leukemia cells. Cancer Lett. 2005 Feb 10;218(2):141-51.
Kaplan M., Hayek T. , Raz A., et al. Pomegranate juice supplementation to apolipoprotein E deficient mice with extensive atherosclerosis reduces macrophages lipid peroxidation, cellular cholesterol accumulation and development of atherosclerosis. J. Nutr. 2001; 131: 2082-2089.
Aviram M. Does paraoxonase play a role in susceptibility to cardiovascular disease? Mol. Med. Today. 1999; 5 (9):381-386.
Aviram M. and Dorenfeld L. Pomegranate juice consumption inhibits serum angiotensin II converting enzyme (ACE) activity and reduces systolic blood pressure. Atherosclerosis. 2001; 158: 195-198.
Aviram M. and Fuhrman B. Flavonoid antioxidants protect LDL from oxidation and attenuate atherosclerosis. Curr. Opin. Lipidol. 2001; 12: 41-48.
Aviram M, and Fuhrman B. Anti-atherogenicity of nutritional antioxidants. Current Drugs 2001; 4: 82-92.
Vaya J. and Aviram M. Nutritional antioxidants and their biomedical applications. Current Medicinal Chemistry : Immunology, Endocrine and Metabolic Agents (CMC-IEMA). 2001;1: 99-117.
Fuhrman B. and Aviram M. Polyphenols and flvaonoids protects LDL against atherogenic modifications. Handbook of Antioxidants Biochemical, Nutritional and Clinical Aspects, 2nd Edition. Cadenas E & Packer L (Eds.) Marcel Dekker, NY(Pub.). 2001;16:303-336.
Aviram M. Polypyhenols from pomegranate juice, red wine and licorice root protect against lipids peroxidation and attenuate cardiovascular diseases. Polyphenols Communciations 2001. XXth International Conference on Polyphenols, Eds. Martens S., Treutter D and Forkmann G. Freising-Weihenstephan, Germany 2002; pp. 158-175.
Aviram M., Dorenfeld L., Kaplan M., et al. Pomegranate juice flavonoids inhibit LDL oxidation and cardiovascular diseases: studies in atherosclerotic mice and in humans. Drugs Under Experimental and Clinical Research, Bioscience, 2002; 28:49-62 (2002).
Aviram M. Pomegranate juice as a major source for polyphenolic flavonoids and it is most potent antioxidant against LDL oxidation and atherosclerosis. In: Proceedings of the 11th Biennal Meeting of the Society for Free Radical Research International ( Paris, France, July 16-20, 2002), by Monduzzi Editore S.p.A. – MEDIMOND Inc. 2002. pp. 523- 528.
Aviram M. Pomegranate juice as a major source for polyphenolic flavonoids and it is most potent antioxidant against LDL oxidation and atherosclerosis. Free Radical Research. 2002; 36 (Supplement 1): 71-72.
Aviram M., Fuhrman B., Rosenblat M., et al. Pomegranate juice polyphenols decreases oxidative stress, low-density lipoprotein atherogenic modifications and atherosclerosis. Free Radical Research. 2002; 36 (Supplement 1): 72-73.
Kawaii S, Lansky EP. 8 Differentiation-promoting activity of pomegranate (Punica granatum) fruit extracts in HL-60 human promyelocytic leukemia cells. J Med Food. 2004 Spring;7(1):13.
Hora JJ, Maydew ER, Lansky EP, Dwivedi C. Chemopreventive effects of pomegranate seed oil on skin tumor development in CD1 mice. J Med Food. 2003 Fall;6(3):157-61.
Kim ND, Mehta R, Yu W, et al. Breast Chemopreventive and adjuvant therapeutic potential of pomegranate (Punica granatum) for human breast cancer. Cancer Res Treat. 2002 Feb;71(3):203-17.
Sastravaha G, Yotnuengnit P, Booncong P, Sangtherapitikul P. Adjunctive periodontal treatment with Centella asiatica and Punica granatum extracts. A preliminary study. J Int Acad Periodontol. 2003 Oct;5(4):106-15.
Vasconcelos LC, Sampaio MC, Sampaio FC, Higino JS. Use of Punica granatum as an antifungal agent against candidosis associated with denture stomatitis. Mycoses. 2003 Jun;46(5-6):192-6.
Mitcheva M, Astroug H, Drenska D, et al. Biochemical and morphological studies on the effects of anthocyans and vitamin E on carbon tetrachloride induced liver injury. Cell Mol Bio 1993;39:443–8.
Maffei F, Carini M, Aldini G, et al. Free radical scavenging action and anti-enzyme activities of procyanidines from Vitis vinifera. A mechanism for their capillary protective action. Arzneimittelforschung 1994;44:592–601.
Baroch J. Effect of Endotelon in postoperative edema. Results of a double-blind study versus placebo in 32 female patients. Ann Chir Polast Esthet 1984;29:393–5 [in French].
Liviero L, Puglisis E. Antimutagenic activity of procyanidins from vitis vinfera. Fitother 1994;65:203–9.
Dartenuc JY, Marache P, Choussat H. Resistance Capillaire en Geriatrie Etude d’un Microangioprotecteur. Bordeaux Médical 1980;13:903–7 [in French].
Delacroix P. Etude en Double Avengle de l’Endotelon dans l’Insuffisance Veineuse Chronique. Therapeutique, la Revue de Medicine 1981;27–28 Sept:1793–802 [in French].
Thebaut JF, Thebaut P, Vin F. Study of Endotelon in functional manifestations of peripheral venous insufficiency. Gazette Medicale 1985;92:96–100 [in French].
Corbe C, Boissin JP, Siou A. Light vision and chorioretinal circulation. Study of the effect of procyanidalic oligomers. J Fr Ophtalmol 1988;11:453–60.
Boissin JP, Corbe C, Siou A. Chorioretinal circulation and dazzling; use of procyanidolic oligomers. Bull Soc Ophtalmol Fr 1988;88:173–4, 177–9 [in French].
Puetter M, Grotemeyer KHM, Wuerthwein G, et al. Inhibition of smoking-induced platelet aggregation by aspirin and pycnogenol. Thromb Res 1999;95:155–61.
Peterson J, Dwyer J. Taxonomic classification helps identify flavonoid-containing foods on a semiquantitative food frequency questionnaire. J Am Diet Assoc 1998;98:682-56. So FV, Guthrie N, Chambers AF, et al. Inhibition of human breast cancer cell proliferation and delay of mammary tumorigenesis by flavonoids and citrus juices. Nutr Cancer 1996;26:167-81.
Reinhold U, Seiter S, Ugurel S, Tilgen W. Treatment of progressive pigmented purpura with oral bioflavonoids and ascorbic acid: an open pilot study in 3 patients. J Am Acad Dermatol 1999;41(2 Pt 1):207-8.
Bar-Meir S, Halpern Z, Gutman M, et al. Effect of (+)-cyanidanol-3 on chronic active hepatitis: a double-blind controlled trial. Gut 1985;26:975–9.
Conn HO. Cyanidanol: will a hepatotrophic drug from Europe go west? Hepatology 1983;3:121–3 [review].
Pamukcu AM, Yalciner S, Hatcher JF, Bryan GT. Quercetin, a rat intestinal and bladder carcinogen present in bracken fern (Pteridium aquilinum). Cancer Res 1980;40:3468–72.
Hirono I, Ueno I, Hosaka S, et al. Carcinogenicity examination of quercetin and rutin in ACI rats. Cancer Lett 1981;13:15–21.
Saito D, Shirai A, Matsushima T, et al. Test of carcinogenicity of quercetin, a widely distributed mutagen in food. Teratog Carcinog Mutagen 1980;1:213–21.
Aeschbacher H-U, Meier H, Ruch E. Nonmutagenicity in vivo of the food flavonol quercetin. Nutr Cancer 1982;2:90.
Nishino H, Nishino A, Iwashima A, et al. Quercetin inhibits the action of 12-O-tetradecanoylphorbol-13-acetate, a tumor promoter. Oncology 1984;41:120–3.
Kuo SM. Antiproliferative potency of structurally distinct dietary flavonoids on human colon cancer cells. Cancer Lett 1996;110:41–8.
Knekt P, Jävinen R, Seppänen R, et al. Dietary flavonoids and the risk of lung cancer and other malignant neoplasms. Am J Epidemiol 1997;146:223–30.
Hertog M, Feskens EJM, Hollman PCH, et al. Dietary flavonoids and cancer risk in the Zutphen Elderly Study. Nutr Cancer 1994;22:175–84.
Stavric B. Quercetin in our diet: from potent mutagen to probable anticarcinogen. Clin Biochem 1994;27:245–8.
Vinson JA, Bose P. Comparative bioavailability to humans of ascorbic acid alone or in a citrus extract. Am J Clin Nutr 1988;48:601–4.
Vinson JA, Bose P. Comparative bioavailability of synthetic and natural vitamin C in guinea pigs. Nutr Rep Int 1983;27:875–9.
Corder, R., W. Mullen, et al. (2006). "Oenology: red wine procyanidins and vascular health." Nature 444(7119): 566.
This website and these statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease. Please consult a properly trained medical practitioner for medical advice.
