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Glucosamine + Chondroitin + MSM
GL5
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What is Glucosamine + Chondroitin + MSM?
Glucosamine promotes the formation and repair of cartilage. Chondroitin promotes water retention and elasticity in cartilage, and inhibits enzymes that break down cartilage and MSM is an anti-inflammatory that eases pain. This formula is one of our most popular and we strongly recommend it.
Glucosamine and Chondroitin were shown in a recent US National Institute of Health study to be highly effective at reducing joint pain. "For a subset of participants with moderate-to-severe pain, glucosamine combined with chondroitin sulfate provided statistically significant pain relief compared to placebo--about 79 percent had a 20 percent or greater reduction in pain versus about 54 percent for placebo."1
Who Should Consider Glucosamine + Chondroitin + MSM?
Anyone who is experiencing Osteoarthritis joint-associated pain, including:
- Knee joint pain;
- Elbow joint pain;
- Finger, joint pain;
- Spinal and neck related arthritic pain;
- Hip related arthritic pain;
- Other related joint/cartilage pain stemming from Oseoarthritis.
Why:
To aid in the relief of pain associated with Osteoarthritis (also known as Degenerative Joint Disease) and to potentially slow the onset of degenerative effect of arthritis. This is a combination that helps in the rebuilding of joint cartilage, maintains the health of the cartilage and at the same time reduces the painful inflammation associated with arthritis.
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Background on Ingredients:
Osteoarthritis, a type of Degenerative Joint Disease, is the most common form of arthritis and is one of the most prevalent diseases in the United States today; affecting some 40 million Americans.
The joints most often affected are the weight bearing joints, such as the knees and hips and the small joints of the hands. The pain, deformity and limitation of movement in these joints is the result of cartilage destruction (a progressive degeneration of cartilage glycosaminoglycans) and the subsequent hardening and formation of bone spurs. There are a number of reasons why osteoarthritis occurs, the main reason being the cumulative effects of years of use of the joints compounded by the inability, as we age, to restore joint cartilage. Much of this reduced function can be directly related to the nutritional status of the individual.
How Does Glucosamine Work?
Numerous double blind studies have shown that Glucosamine produces significantly positive results in reducing the symptoms of Osteoarthritis. The main function of glucosamine is to stimulate the manufacture of substances, including cartilage, necessary for joint repair. It appears that some people lack the ability to manufacture glucosamine and this has been suggested as one of the major factors leading to the development of osteoarthritis. European researchers were the first to study the link between glucosamine levels and osteoarthritis. Of the three ingredients in Glucosamine + Chondroitin + MSM, Glucosamine has the strongest amount of research indicating its efficacy. If you are on a tight budget, Glucosamine alone is a less expensive option. Click here to go to our most popular Glucosamine only product.
How Does Chondroitin Work?
Chondroitin Sulfates are long chains of repeating disaccharides that are sulfated. They are part of a group of glycosaminoglycans, also known as as mucopolysaccharides. They are made up of amino sugars, sugar acid and galactosamine (which is a precursor to glucosamine). The chains of Chondroitin Sulfates are much longer than other glycosaminoglycans. This added length seems to assist in the efficacy of chondroitin. Chondroitin Sulfates have negative charges which cause them to repel each other and attract water, which in turn fills space in three dimensions and enables cartilage to absorb shock. While Glucosamine helps you manufacture or repair cartilage, Chondroitin seems to help maintain its health and lubrication.
Recent Research on Chondroitin is compelling.
For the past seven years we have not sold a product with Chondroitin in it. We have refrained from selling Chondroitin mainly because the research on the efficacy of orally consumed Chondroitin, although building, was not yet compelling. We are now firmly of the opinion that, based on numerous double-blind placebo, controlled studies, adding chondroitin to your supplement regime is a strongly positive factor in reducing the negative effects of arthritis, and we are now including, and recommending, chondroitin in many of our joint formulas.
How Does MSM Work?
Methylsulfonylmethane, or MSM, is a safe and natural assimilate derived from the Southern Louisiana Pine. MSM is organic sulfur--the kind your body can absorb and use. Sulfur is the fourth most plentiful mineral in the body. And, it is found in every cell of every animal and plant. Sulfur is found in food; it is most abundant in eggs and red peppers, but can also be found in significant quantities in grains, legumes, animal proteins, onions, garlic, asparagus, cabbage, brussel sprouts, and broccoli.
At the Oregon Health and Sciences University, Dr. Stanley Jacob discovered that heating dimethyl sulfoxide (DMSO), caused it to crystallize, isolating 99.9% of the beneficial compound MSM. MSM is a pure, natural, stable, white, odorless crystalline powder without the unpleasant taste or odor of DMSO. It does not produce intestinal gas or body odor that may occur with other forms of sulfur. MSM is not a drug or medicine, and is unrelated to sulfa drugs, to which some people have an allergy.
MSM may help relieve joint pain and swelling - without the stomach damage, rebound pain, and (yes, it's true) joint damage associated with non-steroidal anti-inflammatory drugs (NSAID's), such as ibuprofen. But not all MSM is the same - only Lignisul™ brand MSM from Carolwood Corporation is guaranteed at least 99.7% pure as determined by gas chromatographic assay. Every batch produced by Carolwood has been tested. The first food-grade MSM made for human consumption; Lignisul™ remains the finest available.
Why Potassium?
Potassium is a necessary ingredient in the proper manufacturing and bonding of Glucosamine, being part of the formulation itself.
Potassium supplementation is necessary for proper muscle tone, mulsce function and water balance and is an important ingredient in joint health.
Potassium is a very safe supplement, but should not be consumed by people who suffer from kidney disease without proper medical supervision.
Side Effects
Potential users who take blood-thinning agents should review with their physicians before using. NOTE TO THOSE WITH SHELLFISH ALLERGIES: In the June 2004 Edition of the "Drugs and Therapy Bulletin" from Shands at the University of Florida, they stated that most warnings to not use glucosamine if you have a shellfish allergy are based on the assumption that a patient that is allergic to shellfish may also be allergic to glucosamine since glucosamine is made from shellfish. However, this article goes on to state that this warning may be conservative since the antigens in crustaceans and mollusks are proteins and not derivatives of their shells. Also, there have been no published reports about patients with shellfish allergies having negative reactions to glucosamine supplements. However, there are reports of patients experiencing hypersensitivity to glucosamine, so please consult with your physician if you have ever experienced an adverse reaction to glucosamine. (For more information about this study, please visit www.shands.org/professional/drugs/bulletins/0604.pdf.
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Label Facts
Glucosamine + Chonroitin + MSM, 90 Capsules:
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Supplement Facts
Serving Size: 3 Capsules
Servings per container: 30 |
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Amount Per Serving |
% Daily Value |
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| Chloride |
175 mg |
5% |
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| Sodium |
36 mg |
1.5% |
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| Potassium |
193 mg |
5.5% |
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| Glucosamine Sulfate 2KCl |
1500 mg |
† |
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| Chondroitin Sulfate Sodium |
1200 mg |
† |
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| Methylsulfonylmethane (MSM) Lignisul® |
300 mg |
† |
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Other ingredients: Vegetable capsule (HPMC [cellulose], water) and magnesium stearate (vegetable source).
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Allergen Warning
Contains crustacean shellfish (crab, lobster and/or shrimp) product.
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Dietary Restrictions
 Vegetarian capsule used but not a vegetarian formula.
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References
- Clegg, D. O., D. J. Reda, et al. (2006). "Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis." N Engl J Med 354(8): 795-808.
- D'Ambrosio, E., B. Casa, R. Bompani, G. Scali and M. Scali (1981). "Glucosamine sulphate: a controlled clinical investigation in arthrosis." Pharmatherapeutica 2(8): 504-8.
- Leffler, C. T., A. F. Philippi, S. G. Leffler, J. C. Mosure and P. D. Kim (1999). "Glucosamine, chondroitin, and manganese ascorbate for degenerative joint disease of the knee or low back: a randomized, double-blind, placebo-controlled pilot study." Mil Med 164(2): 85-91.
- McAlindon, T. E., M. P. LaValley, J. P. Gulin and D. T. Felson (2000). "Glucosamine and chondroitin for treatment of osteoarthritis: a systematic quality assessment and meta-analysis [see comments]." Jama 283(11): 1469-75.
- Pujalte, J. M., E. P. Llavore and F. R. Ylescupidez (1980). "Double-blind clinical evaluation of oral glucosamine sulphate in the basic treatment of osteoarthrosis." Curr Med Res Opin 7(2): 110-14.
- Vajaradul, Y. (1981). "Double-blind clinical evaluation of intra-articular glucosamine in outpatients with gonarthrosis." Clin Ther 3(5): 336-43.
- Drovanti, A. et. al.; Therapeutic Activity of Oral Glucosamine Sulfate in Osteoarthritis: A Placebo-Controlled, Double-Blind Investigation; Clinical Therapeutics, Vol. 3, No. 4, 1980, pp. 260-272
- Reginster, Jean Yves et. al.; Long-term effects of glucosamine sulphate on osteoarthritis progression: a randomised, placebo-controlled clinical trial; The Lancet, 2001, Vol. 357, No. 9252
- Morreale, P. et. al.; Comparison of the Antiinflammatory Efficacy of Chondroitin Sulfate and Diclofenac Sodium in Patients with Knee Osteoarthritis; Journal of Rheumatology, 1996, 23:8, pp. 1385-1391
- Bourgeois P, et al. Efficacy and tolerability of chondroitin sulfate 1200 mg a day versus chondroitin sulfate three times 400 mg a day versus placebo. Osteoarthritis and Cartilage 1998;69(A):25-30.
- Vergruggen G, et al. Chondroitin sulfate: structure/disease modifying antiarthritis drug in the treatment of finger joint OA. Osteoarthritis and Cartilage 1998;6(A):37-8.
- Bucsi L, Poor G. Efficacy and tolerability of oral chondroitin sulfate as a symptomatic slow-acting drug for osteoarthritis in the treatment of knee osteoarthritis. Osteoarthritis and Cartilage 1998;6(A):31-6.
- Uebelhart D. Effects of oral chondroitin sulfate on the progression of knee osteoarthritis: a pilot study. Osteoarthritis and Cartilage 1998;68(A):39-46.
- Uebelhart D, Thonar EJ, Delmas PD, Chantraine A, Vignon E., Effects of oral chondroitin sulfate on the progression of knee osteoarthritis: a pilot study. Department of Neuclid, University Hospital of Geneva, Switzerland.
- Bucsi L, Poor, G., Efficacy and tolerability of oral chondroitin sulfate as a symptomatic slow-acting drug for osteoarthritis (SYSADOA) in the treatment of knee osteoarthritis. Osteoarthritis Cartilage. 1998 May;6 Suppl A:31-6.
- Bourgeois P, Chales G, Dehais J, Delcambre B, Kuntz JL, Rozenberg S., Efficacy and tolerability of chondroitin sulfate 1200 mg/day vs chondroitin sulfate 3 x 400 mg/day vs placebo. Arch Intern Med. 2004 Feb 9;164(3):338-9; author reply 339.
- Richy F, Bruyere O, Ethgen O, Cucherat M, Henrotin Y, Reginster JY. Structural and symptomatic efficacy of glucosamine and chondroitin in knee osteoarthritis: a comprehensive meta-analysis. Drugs Exp Clin Res. 2004;30(1):11-6.
- Rovetta G, Monteforte P, Molfetta G, Balestra V. A two-year study of chondroitin sulfate in erosive osteoarthritis of the hands: behavior of erosions, osteophytes, pain and hand dysfunction. Osteoarthritis Cartilage. 2004 Apr;12(4):269-76.
- Uebelhart D, Malaise M, Marcolongo R, DeVathaire F, Piperno M, Mailleux E, Fioravanti A, Matoso L, Vignon E. Intermittent treatment of knee osteoarthritis with oral chondroitin sulfate: a one-year, randomized, double-blind, multicenter study versus placebo. J Rheumatol. 2001 Jan;28(1):173-81.
- Reginster J-Y, Deroisy R, Paul I, Lee RL, Henroitoin Y, Giacovelli G, et al. Glucosamine sulfate significantly reduces progression of knee osteoarthritis over 3 years: a large, randomised, placebo-controlled, prospective trial. Arthritis Rheum 1999;42:S400.
- Pavelka K, Olejarova M, Machacek S, Giacovelli G, Rovati LC. Glucosamine sulfate decreases progression of knee osteoarthritis in a long-term randomised placebo-controlled trial. Arthritis Rheum 2000;43:S384.
Glucosamine and Chondroitin References / Additional Resources
- (1998). "[Gonarthrosis--current aspects of therapy with glucosamine sulfate (dona200-S)]." Fortschr Med Suppl 183: 1-12.
- (1999). "Glucosamine sulfate." Altern Med Rev 4(3): 193-5.
- Baici A et al. Analysis of gylcosaminoglycans in human sera after oral administration of chondroiton sulfate. Rheumatol Int 1992. 12:81-8.
- Bassleer, C., L. Rovati and P. Franchimont (1998). "Stimulation of proteoglycan production by glucosamine sulfate in chondrocytes isolated from human osteoarthritic articular cartilage in vitro." Osteoarthritis Cartilage 6(6): 427-34.
- Conte A et al. Biochemical and pharmacokinetic aspects of oral treatment with chondroiton sulfate. Arzneim Forsch. 1995. 45:918-25.
- D'Ambrosio, E., B. Casa, R. Bompani, G. Scali and M. Scali (1981). "Glucosamine sulphate: a controlled clinical investigation in arthrosis." Pharmatherapeutica 2(8): 504-8.
- da Camara, C. C. and G. V. Dowless (1998). "Glucosamine sulfate for osteoarthritis [see comments]." Ann Pharmacother 32(5): 580-7.
- Houpt, J. B., R. McMillan, C. Wein and S. D. Paget-Dellio (1999). "Effect of glucosamine hydrochloride in the treatment of pain of osteoarthritis of the knee [see comments]." J Rheumatol 26(11): 2423-30.
- Kelly, G. S. (1998). "The role of glucosamine sulfate and chondroitin sulfates in the treatment of degenerative joint disease." Altern Med Rev 3(1): 27-39.
- McAlindon, T. E., M. P. LaValley, J. P. Gulin and D. T. Felson (2000). "Glucosamine and chondroitin for treatment of osteoarthritis: a systematic quality assessment and meta-analysis [see comments]." Jama 283(11): 1469-75.
- McCarty, M. F. (1998). "Enhanced synovial production of hyaluronic acid may explain rapid clinical response to high-dose glucosamine in osteoarthritis." Med Hypotheses 50(6): 507-10.
- Murray, Michael, ND, Pizzorno, Joseph, ND. Encyclopedia of Natural Medicine, second ed. Prima Publishing, Rocklin. 1998.
- Qiu, G. X., S. N. Gao, G. Giacovelli, L. Rovati and I. Setnikar (1998). "Efficacy and safety of glucosamine sulfate versus ibuprofen in patients with knee osteoarthritis." Arzneimittelforschung 48(5): 469-74.
- Setnikar et al. Pharmacokinetics of glucosamine in man. Arzneim Forsch. 1993. 43(10):1109-13.
- Tapadinhas, M. J., I. C. Rivera and A. A. Bignamini (1982). "Oral glucosamine sulphate in the management of arthrosis: report on a multi-centre open investigation in Portugal." Pharmatherapeutica 3(3): 157-68.
- Vidal y Plana, R. R. and K. Karzel (1980). "[Glucosamine: its importance for the metabolism of articular cartilage. 2. Studies on articular cartilage]." Fortschr Med 98(21): 801-6.
- Mindell, E. L., The MSM Miracle: Enhance your health with organic sulfur. Keats Publishing, New Canaan, CT, 1997.
- Azuma, J.; Sawamura, A.; Awata, N.; Hasegawa, H.; Ohta, H.; Yamauchi, K.; Kishimoto, S., "Double-blind Randomized Crossover Trial of Taurine in Congestive Heart Failure," Cur. Thera. Resrch., 1983.
- Bartfeld, I. J., Goldstein, A., "Cell-mediated Immunity: Its Modulation by Dimethylsulfoxide," Ann. N. Y. Acad. Sci., 1975.
- Childs, S. J., "Dimethylsulfone (DSM02) in the Treatment of INterstitial Cystitis." Urol. Clin. North Am., 1994.
- Cooper, A., "Biochemistry of Sulfur-containing Amino Acids," Ann. Rev. Biochem., 1983.
- D'Ambrosia, E, Casa, B., Bompani R., Scali, M., "Glucosamine Sulphate: A Controlled Clinical Investigation in Arthosis," Pharmatherapeutica, 1981.
- Herschler, R. J., "Methysulfonylmethane and Methods of Use," United States Patent 4,296,130: 1981.
- Herschler, R. J., "Methysulfonylmethane and Compositions Comprising It," United States Patent 4,616,039: 1986.
- Herschler, R. J., "Dietary and Pharmaceutical uses of Methysulfonylmethane Compositions Comprising It," United States Patent 4,512,421:
- Jacob, S. W., "The Current Status of MSM in Medicine," Am. Acad. Meri. Prev., 1983.
- Jacob, S. W., Herschler R. J., "Introdry Remarks: Dimethylsulfoxide After Twenty Years," Ann. N. Y. Acad. Sci., 1983.
- Kharasch, N., Thyagarajan, B. S., "Structural Basis for Biological Activities of Dimethylsulfoxide," Ann. N. Y. Acad. Sci., 1983.
- Klein, H. A., Samant, S., Herz, B. L., Pearlman, H. S., "Dimethylsulfoxide in Adult Respiratory Stress Syndrome," Ann. N. Y. Acad. Sci., 1983.
- Koesis, J. J., Harkaway, S, Snyder, R., "Biological Effects of the Metabolites of Dimethylsulfoxide," Ann. N. Y. Acad. Sci., 1975.
- Metcalf, J. W., "MSM--A Dietary Derivative of DSMO," J. Eq. Vet. Sci., 1983.
- Metcalf, J. W., "MSM Status Report," Eq. Vet. Data, 1986.
- Miura K et al., "Cystine Uptake and Glutathione Level in Endothelial Cells Exposed to Oxidative Stress," Am. J. Physiol., 1992.
- Morton, J. i., Siegel, B. V., "Effects of Oral Dimethylsulfoxide and Dimethylsulfone on Murine Autoimmune Lymphoproliferative Disease," Proc. Soc. Exper. Bio. Med., 1986.
- Nagasawa, H., "The In Vitro and In Vivo EffectS Dimethylsulfoxide on the Pituitary Secretion of Growth Hormone and Prolactin in Mice," Ann. N. Y. Acad. Sci., 1983.
- Pearson, T. W., Dawson, H. J., Lackey, H. B., "Natural Occurring Levels of Dimethylsulfoxide in Selected Fruits, Vegetables, Grains and Beverages," J. Agric. Food Chem., 1981.
- Repine, J. E., Fox, R. B., Berger, E. M., "Effect of Dimethylsulfoxide on the Bactericidal Function of Polymorphonuclear Leukocytes," Ann. N.Y. Acad. Sci., 1983.
- Richmond , V. L., "lncorporation of Methylsulfonylmethane Into Guinea Pig Serum Proteins," Life Sciences, 1986.
- Richmond , V. L., "Incorporation of Methylsulfonylmethane into Guinea Pig IgG, Transferrin and Albumin Fractions and Tissues," Seattle, Wash: Pacific Northwest Research Foundation.
- Sellnow, I., "MSM--An Aid From Nature," Canadian Horseman, 1989.
- Tapadinhas, M. J., Rivera, I. C., Bignamini, A. A., "Oral Glucosamine Sulfate in the Management of Arthrosis," Report on a Multi-center Open Investigation in Portugal, 1982. IL
- Teigland, M. B., Saurino, V. R., "Clinical Evaluation of Dimethylsulfoxide in Equine Applications," Ann. N. Y. Acad. Sci., 1975.
- Voaden. M. J; Hussain. A.A.; Chan, I. P. R. "Studies on Retinitis Pigmentosa in Man. I. Taurine and Blood Platelets." Brit. J. Opthal., 1982.
- Williamson, J., Boettcher, B., Meister, A., "lntracellular Cysteine Delivery System that Protects Against Toxicity by Promoting Glutathione Synthesis," Proc. Nat. Acad. Sci., 1982.
- Wright, J., Littleton, K., "Defects in Sulfur Metabolism," Intl. Clin. Nutr. Rev., 1989.
- Wright, J., Kirk, F. R., "Defects in Sulfur Metabolism II: Apparent Failure of Sulphate Conjugation," Intl. Clin. Nutr. Rev., 1989.
- Ronca F, et al. Anti-inflammatory activity of chondroitin sulfate. Osteoarthritis and Cartilage 1998;69(A):14-21.
- Bucci LR. Pain-Free. Ft. Worth, TX: The Summit Group, 1995.
- Theodosakis, Adderly, and Fox. The Arthritis Cure. New York: St. Martin's Press, 1997.
- Theodosakis, Jason, Better Nutrition, May 2002.
- Priebe, David, McDiarmid, Todd, Mackler, Leslie, “ Do glucosamine or chondroitin cause regeneration of cartilage in osteoarthritis?”, Journal of Family Practice
- (1.) Towheed TE, Anastassiades TP, Shea B, Houpt J, Welch V, Hochberg MC. Glucosamine therapy for treating osteoarthritis. Cochrane Database Syst Rev 2001: CD002946.
- Hauselmann, HJ. Nutripharmaceuticals for osteoarthritis. Best Pract Res Clin Rheumatol 2001; 15:595-607.
- de los Reyes GC, Koda RT, Lien EJ. Glucosamine and chondroitin sulfates in the treatment of osteoarthritis: a survey. Prog Drug Res 2000; 155:81-103.
- Jubb, RW. Oral and intra-articular remedies: review of papers published from March 2001 to February 2002. Curr Opin Rheumatol 2002; 14:597-602.
- Reginster, JY, Deroisy R, Rovati LC, et al. Long-term effects of glucosamine sulphate on osteoarthritis progression: a randomised, placebo-controlled clinical trial. Lancet 2001; 357:251-256.
- Mazzuca SA, Brandt KD, Lane KA, Katz BP. Knee pain reduces joint space width in conventional standing antero-posterior radiographs of osteoarthritic knees. Arthritis Rheum 2002; 46:1223-1227.
- Verbruggen, G, Goemaere S, Veys EM. Systems to assess the progression of finger joint osteoarthritis and the effects of disease modifying osteoarthritis drugs. Clin Rheumatol 2002: 21:231-243.
- Recommendations for the medical management of osteoarthritis of the hip and knee: 2000 update. American College of Rheumatology Subcommittee on Osteoarthritis Guidelines. Arthritis Rheum 2000; 43:1905-1915.
- Problems with dietary supplements. Med Lett Drugs Ther 2002; 44:84-86.
- McAlindon TE, LaValley MP, Gulin JP, Felson DT. Glucosamine and chondroitin for treatment of osteoarthritis. JAMA 2000;283:1469-75.
- van Blitterswijk WJ, van de Nes JC, Wuisman PI, Glucosamine and chondroitin sulfate supplementation to treat symptomatic disc degeneration: biochemical rationale and case report, BMC Complement Altern Med. 2003 Jun 10;3(1):2.
- Hungerford DS, Jones LC, Glucosamine and chondroitin sulfate are effective in the management of osteoarthritis, J Arthroplasty. 2003 April; 18 (2 Suppl 1):5-9.
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