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Gugulipid® Guggulsterones
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What is Gugulipid® Guggulsterones?
Gugulipid® standardized gugulu and guggulsterone. A silly name, a serious application with an ancient pedigree, having references in the ancient Indian system of Ayurveda medicine. Guggulsterones act to reduce LDL and triglycerides (and may increase HDL). Guggulsterones increase the liver's capacity to pick up and eliminate LDL from the blood stream. Guggulsterone stereoisomers -E and -Z are FXR bile acid receptor antagonist ligands. It is also a very good antioxidant.
Who Should Consider Gugulipid® Guggulsterones?
Guggulsterones increase the liver's capacity to pick up and eliminate LDL from the blood stream. (For those keeping score, it is likely that the guggulsterone stereoisomers -E and -Z are FXR bile acid receptor antagonist ligands.) It is also a very good antioxidant. It is an excellent choice for those few who do not respond to Octacosanol.
Related Articles
- Gugulipid May Help Protect Prostate
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In a recent study published in the the journal Molecular Pharmacology, researchers found that gugulipid may inhibit prostate cancer cell proliferation.
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All About Gugulipids®!
The Gugulexicon:
Source: a tree native to India known scientifically as Commiphora wightii, previously known in scientific literature as Commiphora mukul, commonly referred to as the mukul myrrh tree, as in the myrrh used in making incense.
"Guggulu" or "Gum Guggul": Unrefined resin from said tree
"Gugulipid®: Ethyl acetate extract of Guggulu, a registered trademark of Sabinsa Corporation.
"Guggulsterone": Lipid and cholesterol lowering fraction of Gugulipid®
Silly name, serious application. This substance has an ancient pedigree, having references in the ancient Indian system of medicine known as Ayurveda. Guggulsterones act to reduce LDL and triglycerides (and may increase HDL).
Is Gugulipid Safe?
If you have done some research you may know that the crude Gum Guggul is somewhat toxic. However, its extract, Gugulipid has a safety profile that is comparable to that of Policosanol! (Interestingly, the Ayurveda recommends an extract to eliminate toxicity, a suggestion dating back 2000 years). In other words, NO toxicty has been shown in the Gugulipid reduction. However, women who are pregnant should not take this product because it may stimulate menstrual flow and the uterus. Lactating women should also not take this product because of insufficient safety data.
Should I Start With Policosanol, Phytosterols or Gugulipid®?
This is a tough choice. Let's look at the pros and cons:
Policosanol and Phytosterols have never shown a hint of a side effect, while Guggulsterones have caused a very few number of trial subjects some stomach complaints and a headache or two (the number reporting these symptoms is considered statistically insignificant). Policosanol works in the 10-20mg/day range, whereas Guggulsterones are active at about 75mg/day. Phytosterols are effective at about 800mg/day. Policosanol and Phytosterols are very well studied by the Western model of double-blind, placebo-controlled trial, whereas Guggulsterones have a 2000 year history of use in India where they are also now recognized by the Indian government for use as a lipid-lowering agent. The U.S. FDA permits products containing sufficient levels of phytosterols to make claims regarding cardiovascular health. Guggulsterones have an additional benefit that is not often mentioned: they are an anti-inflammatory agent roughly equal in potency to ibuprofen. Still not sure? Start with Policosanol and Phytosterols, and if you do not have the results you want in 2-4 months, try Gugulipid®.
Side Effects
Guggulsterones have caused very few side effects in trial subjects. Some stomach complaints and a headache or two have been reported (the number reporting these symptoms is considered statistically insignificant).
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Label Facts
Gugulipid, 750mg, 60 Capsules:
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Supplement Facts
Serving Size: 2 Capsules
Servings per container: 30 |
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Amount Per Serving |
% Daily Value |
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| Guggulipid Standardized Extract (from Commiphora wightii) (10% Guggulsterones) |
1500 mg |
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Other ingredients: Vegetable capsule (HPMC [cellulose], water), cellulose (plant fiber), magnesium stearate (vegetable source), and silicon dioxide.
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Dietary Restrictions
 Vegetarian capsule used and a vegetarian formula.
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References
- Beg, M., K. C. Singhal, et al. (1996). "A study of effect of guggulsterone on hyperlipidemia of secondary glomerulopathy." Indian J Physiol Pharmacol 40(3): 237-40.
- Cui, J., L. Huang, et al. (2003). "Guggulsterone is an FXR antagonist in coactivator association assays but acts to enhance transcription of bile salt export pump." J Biol Chem.
- Dixit, V. P., S. Joshi, et al. (1980). "Hypolipidemic activity of guggal resin (Commiphora mukul) and garlic (Alium sativum linn.) in dogs (Canis familiaris) and monkeys (Presbytis entellus entellus Dufresne)." Biochem Exp Biol 16(4): 421-4.
- Kaul, S. and N. K. Kapoor (1989). "Cardiac sarcolemma enzymes & liver microsomal cytochrome P450 in isoproterenol treated rats." Indian J Med Res 90: 62-8.
- Khanna, D. S., O. P. Agarwal, et al. (1969). "A biochemical approach to anti-atherosclerotic action of Commiphora-mukul: an Indian indigenous drug in Indian domestic pigs (Sus scrofa)." Indian J Med Res 57(5): 900-6.
- Lata, S., K. K. Saxena, et al. (1991). "Beneficial effects of Allium sativum, Allium cepa and Commiphora mukul on experimental hyperlipidemia and atherosclerosis--a comparative evaluation." J Postgrad Med 37(3): 132-5.
- Malhotra, C. L., Y. K. Agarwal, et al. (1970). "The effect of various fractions of gum guggul on experimentally produced hypercholesteraemia in chicks." Indian J Med Res 58(3): 394-5.
- Malhotra, S. C. and M. M. Ahuja (1971). "Comparative hypolipidaemic effectiveness of gum guggulu (Commiphora mukul) fraction 'A', ethyl-P-chlorophenoxyisobutyrate and Ciba-13437-Su." Indian J Med Res 59(10): 1621-32.
- Mehta, V. L., C. L. Malhotra, et al. (1968). "The effects of various fractions of gum guggul on experimentally produced hypercholestraemia in chicks." Indian J Physiol Pharmacol 12(3): 91-5.
- Nityanand, S. and N. K. Kapoor (1971). "Hypocholesterolemic effect of Commiphora mukul resin (guggal)." Indian J Exp Biol 9(3): 376-7.
- Nityanand, S. and N. K. Kapoor (1973). "Cholesterol lowering activity of the various fractions of the guggal." Indian J Exp Biol 11(5): 395-6.
- Satyavati, G. V., C. Dwarakanath, et al. (1969). "Experimental studies on the hypocholesterolemic effect of Commiphora mukul. Engl. (Guggul)." Indian J Med Res 57(10): 1950-62.
- Singh, R. B., M. A. Niaz, et al. (1994). "Hypolipidemic and antioxidant effects of Commiphora mukul as an adjunct to dietary therapy in patients with hypercholesterolemia." Cardiovasc Drugs Ther 8(4): 659-64.
- Singh, V., S. Kaul, et al. (1990). "Stimulation of low density lipoprotein receptor activity in liver membrane of guggulsterone treated rats." Pharmacol Res 22(1): 37-44.
- Urizar, N. L., A. B. Liverman, et al. (2002). "A natural product that lowers cholesterol as an antagonist ligand for FXR." Science 296(5573): 1703-6.
- Verma, S. K. and A. Bordia (1988). "Effect of Commiphora mukul (gum guggulu) in patients of hyperlipidemia with special reference to HDL-cholesterol." Indian J Med Res 87: 356-60.
Gugulipid Double-Blind Placebo-Controlled Trials
- Nityanand, S., J.S. Srivastava, and O.P. Asthana, Clinical trials with gugulipid. A new hypolipidaemic agent. J Assoc Physicians India, 1989. 37(5): p. 323-8.
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