Leptin is a hormone produced by adipocytes (fat cells) that regulates body fat storage by modulating satiety, glycemic control and metabolism. Leptin regulates appetite by binding to sites in a region of brain called the hypothalamus. Leptin triggers the sensation of satiety, giving the feeling of having eaten enough.(Sahu, 2003) Generally speaking, when a person is properly nourished, serum leptin levels increase, and hunger levels decrease. Additionally, leptin plays a role in metabolic regulation and helps the body utilize stored fat.(Wang, 2005)

If everything is working properly, when the body has accumulated enough stored fat, adipocytes release leptin. The leptin crosses the blood brain, signaling you to stop eating sooner which stops the accumulation of fat.

Leptin Resistance is a chronic inflammatory problem that can lead to slow, steady weight gain. When researchers began investigating the role of leptin in the body, they quickly ran into a paradox. While leptin is known to control hunger, researchers found that overweight people frequently have extremely elevated plasma leptin levels. As counterintuitive as this seems, researcher were able to determine that leptin resistance was responsible for this problem.

Much in the same way type-2 diabetics become insulin resistant, people can become leptin resistant. Unlike diabetics, treatment isn't as simple as injecting more leptin into the body. The problem is two-fold. First obesity and weight gain are associated with higher inflammation. The higher inflammation is associated with higher levels of C-Reactive Protein (CRP). A 2006 study conducted by researchers at the University of Pittsburgh shows that elevated levels of CRP inhibit leptin's role in controlling appetite.(Chen, 2006) CRP aggressively binds to leptin, creating a large molecule that cannot cross the blood-brain barrier to the hypothalamus. Therefore the leptin never gets to the hypothalamus and the body never gets the message to stop eating. This in turn leads to more weight gain which causes more and more leptin and CRP to be produced, inflammation levels soon elevate, cholesterol and triglyceride levels increase, and a feedback loop is created that leads to more and more weight gain, higher and higher CRP, cholesterol levels, and triglycerides, and of course, greater leptin resistance.

LeptiCore® is a patented, proprietary blend of plant polysaccharides, esterified fatty acids, pomegranate polyphenols, beta carotene, Klamath blue green algae and phenylethylamine that work synergistically to reduce leptin resistance and CPR and increase satiety.

LeptiCore® also enhances cell membrane stability for improved cellular communication between the liver and adipose tissues for enhanced fatty acid utilization leading to regional fat loss. In addition, modulation of membrane-based inflammatory markers helps to reduce the inflammatory component of fat gain. It is here that LeptiCore® differs from other leptin regulating supplements: the ingredients in LeptiCore®’s proprietary blend have been shown to reduce CRP.

Other benefits of Lepticore’s weight loss formula is the ability to curb the appetite and address emotional eating. Serotonin, a vital neurotransmitter, is involved in a wide range of behavioral functions in the body, including mood, sleep and appetite control. Studies show that serotonin affects eating behavior and body weight. Increased plasma levels of serotonin are associated with decreased food intake, reduced weight gain and increased energy expenditure. Phenylethylamine (PEA) is an endogenous neuromodulating compound known to increase natural serotonin concentration and elevate mood. PEA is the compound found in dark chocolate that provides the feeling of well being.

In a yet-to-be-published, randomized, double-blind, placebo-controlled 8-week clinical study involving 90 obese men and women, LeptiCore® showed some impressive results. Over the course of the study, participants in the LeptiCore® group saw a 6.95% reduction in body weight (an average of 14.5 pounds), a 4% decrease in body fat levels, and a 2-inch reduction in average waist and hip circumference. But that's not all, plasma total cholesterol levels were reduced by an average of 27.48%. Plasma LDL ("bad") cholesterol levels were reduced by an average of 19.77% while plasma HDL ("good") cholesterol was increase by an average of 19.12%. Plasma triglyceride levels were decreased by 16.45%. Perhaps most importantly, C-Reactive Protein levels were reduced by nearly 30%, while serotonin levels were increased by nearly 39%. The results are nothing short of astounding. LeptiFit™ combines LeptiCore® with the other ingredients to for even greater results and cardiac support.

Over the past decade, green tea and green tea extract have been the subject of a significant amount of research. Studies have linked green tea polyphenols to a myriad of potential benefits, including reduced risk of "all-cause mortality." (Kuriyama, 2006) However, our reason for including it in this formula are two-fold: studies have found that green tea may aid in weight loss, and it may provide cardiac benefits.(Alexopoulos, 2008)

L-Theanine is an amino acid that, like phosphatidyl serine, works in the brain. It readily crosses the blood brain barrier and increases the production of Gamma-aminobutyric acid (GABA), increases levels of dopamine and serotonin, and thus creates a feeling of relaxation and well being without drowsiness. There is also evidence that it may increase alpha-wave production in the brain, the brain wave cycle that occurs during periods of relaxation, sleep initiation, and waking. Therefore l-Theanine may help improve sleep.

L-Carnitine

L-Carnitine is an amino acid-like substance. It bears many resemblances to amino acids and is usually grouped under this heading. However, L-Carnitine is not used as a neurotransmitter or in protein synthesis and therefore does not meet the definition of an amino acid. L-Carnitine increases muscle strength and energy, and helps the body to burn fat more efficiently. It is used by the body to transport long chain fatty acids to the mitochondria in your cells, where the fatty acids are used to create energy. Since this fat burning is such a major source of muscular energy, deficiencies in L-Carnitine are manifested as low energy levels and muscular weakness. L-Carnitine deficiencies can also appear as mental confusion or cloudiness, heart pain and weight gain. L-Carnitine seems to help support a healthy heart, and it is well known to help in the treatment of heart pain (usually induced by physical stress). L-Carnitine may also be helpful to the liver and heart in several ways, most notably by helping to prevent fatty build-ups in the heart and liver.