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Niacin
NI1
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IN STOCK - YES
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What is Niacin?
Niacin is used to promote healthy cholesterol levels, support circulatory problems, and maintain skin health. Niacin has antioxidant properties, and is involved in energy production, cholesterol and carbohydrate metabolism, regulation of blood sugar, and detoxification. Inositol Hexanicotinate is a formulation of niacin that provides the benefits of niacin without the common niacin side effects of unpleasant skin flushing and gastric irritation associated with niacin supplements.
Who Should Consider Niacin?
- People with high cholesterol and triglycerides in blood
- People with poor circulation
- People more than 55 years old with poor dietary intake
- People with vertigo and/or tinnitus
- People who abuse alcohol or other drugs
Why?
Niacin, a B-vitamin, nutritional supports healthy cholesterol levels, improved blood flow and promotes healthy skin.
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What is Niacin and Inositol Hexanicotinate?
Vitamin B 3, or niacin, is a water soluble vitamin involved in energy production through fat, cholesterol and carbohydrate metabolism, regulation of blood sugar, detoxification and has antioxidant properties. The body manufactures niacin from the amino acid tryptophan. Rich sources of tryptophan include organ meat, eggs, milk fish and peanuts. There is generally enough niacin absorbed by the body from food to carry out basic functions.
Vitamin B 3 is available in nutritional supplements as niacin (nicotinic acid or nicotinate) or niacinamide (nicotinamide). It is important to note that each form has different applications and can support numerous disorders from high cholesterol levels to arthritis to early-onset type I diabetes.
Inositol Hexanicotinate is a special formulation of niacin that provides the benefits of niacin without the common niacin side effects of unpleasant skin flushing and gastric irritation associated with niacin supplements.
Why do I need Flush-Free Niacin?
Niacin and inositol hexaniacinate are primarily used to:
- Promote healthy cholesterol levels
- Support Raynaud’s phenomenon and other circulatory problems
- Maintain skin health
Healthy Cholesterol Levels
Researchers have recognized niacin use to be beneficial in reducing the risk of heart disease. Niacin can be especially effective in reducing low-density lipoprotein, LDL, the 'bad' cholesterol, and triglycerides while simultaneously raising the high-density lipoprotein, HDL, the 'good' cholesterol levels. Physiologically speaking, niacin can decrease fatty acid mobilization from adipose tissue resulting in a reduction of triglycerides, low density lipoprotein and LDL cholesterol. This B-vitamin appears to raise HDL cholesterol by reducing hepatic apolipoprotein A-l clearance and enhancing reverse cholesterol transport. In a study comparing the safety and efficacy of niacin to the lipid lowering drug, Lovastatin, 136 patients with high cholesterol participated in a controlled, randomized, open label 26 week study. At the end of the test, niacin reduced LDL cholesterol and lipoprotein by 23% and 35%, respectively, while increasing HDL cholesterol by 33%. Lovastatin reduced LDL cholesterol by 32%; there was no reduction in lipoprotein and HDL cholesterol increased by 7%. While lovastatin produced a greater effect on LDL cholesterol reduction, niacin provided better overall results.
Support Healthy Circulation Function
The specialized form of niacin, inositol hexaniacinate, has been used successfully to promote healthy circulation through its ability to relax tightened blood vessels. For those suffering from Raynaud's phenomena, niacin has been shown to dilate the small, constricted arteries hypersensitive to the cold to supply normal amounts of blood and oxygen to the hands and feet. Niacin has also been used to improve circulation for those afflicted with intermittent claudication, a painful cramp in the calf when walking caused by insufficient supply of oxygen to the calf muscle.
Promote healthy skin
Pellagra is an Italian word for 'skin that is rough'. A long-term niacin deficiency can result in this skin disorder distinguished by small patches of cracked, scaly skin. Other symptoms include loss of appetite, sore red tongue, gastrointestinal disturbance and emotional dementia. Pellagra is now a rare occurrence in the western world.
How much niacin do I need?
We recommend that you take 2 Vcaps per day.
Side Effects
Inositol hexaniacinate is the safest form of niacin available. Short and long term studies show it is virtually free of side effects, including the niacin flush and mild gastric upsets.
Do not take if:
- You are allergic to niacin
- Have impaired liver function
- Have an active peptic ulcer
- If you're pregnant or lactating
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Label Facts
Flush-Free Niacin, 60 Capsules:
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Supplement Facts
Serving Size: 2 Capsules
Servings per container: 30
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Amount Per Serving |
% Daily Value |
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| Niacin (from Inositol Hexanicotinate) |
500 mg |
2500%
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| Inositol (from Inositol Hexanicotinate) |
135 mg |
† |
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Other ingredients: Rice flour, vegetable capsule (HPMC [cellulose], water), cellulose (plant fiber),
stearic acid (vegetable source), guar gum, silica, and magnesium stearate (vegetable source).
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Dietary Restrictions
 Vegetarian capsule used and a vegetarian formula.
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References
- Murrary M. Niacin, Vitamin B3 Encyclopedia of Nutritional Supplements 1996:10;88-99.
- DiPalma JR, Thayer WS. Use of niacin as a drug. Annu Rev Nutr 1991:11,169-187
- McKenney J. Niacin for dyslipidemia: considerations in product selection. Am J Health Syst Pharm. 2003 May 15;60(10):995-1005.
- Lovastatin Study Groups I through IV, Lovastatin 5-year safety and efficacy study. Arch Intern Med 1993: 153,1079-1087.
- Berra K. Clinical update on the use of niacin for the treatment of dyslipidemia. J Am Acad Nurse Pract. 2004 Dec;16(12):526-34.
- Bays H. Existing and investigational combination drug therapy for high-density lipoprotein cholesterol. Am J Cardiol. 2002 Nov 20;90(10B):30K-43K.
- Davidson MH, Toth PP. Comparative effects of lipid-lowering therapies. Prog Cardiovasc Dis. 2004 Sep-Oct;47(2):73-104.
- Meyers CD, Kamanna VS, Kashyap ML. Niacin therapy in atherosclerosis. Curr Opin Lipidol. 2004 Dec;15(6):659-65.
- Malik S, Kashyap ML. Niacin, lipids, and heart disease. Curr Cardiol Rep. 2003 Nov;5(6):470-6.
- McKenney JM, Proctor JD, Harris S, Chinchili VM. A comparison of the efficacy and toxic effects of sustained—vs immediate-release niacin in hypercholesterolemic patients. JAMA 1994;271:672–7.
- Knopp RH, Ginsberg J, Albers JJ, et al. Contrasting effects of unmodified and time-release forms of niacin on lipoproteins in hyperlipidemic subjects: clues to mechanism of action of niacin. Metabolism 1985;34:642–50.
- Gray DR, Morgan T, Chretien SD, Kashyap ML. Efficacy and safety of controlled-release niacin in dyslipoproteinemic veterans. Ann Intern Med 1994;121:252–8.
- Rader JI, Calvert RJ, Hathcock JN. Hepatic toxicity of unmodified and time-release preparations of niacin. Am J Med 1992;92:77–81 [Review].
- Knopp RH. Niacin and hepatic failure. Ann Intern Med 1989;111:769 [letter].
- Goldberg A, Alagona P Jr, Capuzzi DM, et al. Multiple-dose efficacy and safety of an extended-release form of niacin in the management of hyperlipidemia. Am J Cardiol 2000;85:1100–5.
- Garg R, Malinow M, Pettinger M, Upson B, Hunninghake D. Niacin treatment increases plasma homocyst(e)ine levels. Am Heart J 1999;138:1082–7.
- Brown WV. Niacin for lipid disorders. Postgrad Med 1995;98:185–93 [review].
- Welsh AL, Ede M. Inositol hexanicotinate for improved nicotinic acid therapy. Int Record Med 1961;174:9–15.
- Head KA. Inositol hexaniacinate: a safer alternative to niacin. Alt Med Rev 1996;1:176–84 [review].
- Murray M. Lipid-lowering drugs vs. Inositol hexaniacinate. Am J Natural Med 1995;2:9–12 [review].
- Herrick AL. Treatment of Raynaud's phenomenon: new insights and developments. Curr Rheumatol Rep . 2003 Apr;5(2):168-74.
- Merritt, WH. Comprehensive management of Raynaud's syndrome. Clin Plast Surg. 1997 Jan;24(1):133-59. Review.
- Hulshof JH, Vermij P. The effect of nicotinamide on tinnitus: a double-blind controlled study. Clin Otolaryngol 1987 Jun;12(3):211-4.
- Belal A Jr, Glorig A. Dysequilibrium of ageing (presbyastasis). J Laryngol Otol. 1986 Sep;100(9):1037-41.
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